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The study shows that the bodys own GLP-1 hormone is present only in very small amounts in the joints

GLP-1 activation enhances insulin secretion during periods of high blood sugar and assists in maintaining stable glucose levels post-meal

Contacting a healthcare provider is necessary if side effects persist, if severe or unusual symptoms appear, if blood sugar levels are not well controlled, or if there are problems with the injection pen

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Most importantly, it is essential for mechanistic insight that is supposed to have translational potential to keep in mind the clinical relevance of the experimental design and how the data generated can be reconciled with other published reports

Summary NHS + NICE evidence supports the safe combined use of Metformin and GLP-1 therapies